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Lemborexant is a dual orexin antagonist indicated for the treatment of sleep-onset and/or sleep maintenance insomnia. By blocking the activity of orexin, a neuropeptide responsible for regulating wakefulness, Lemborexant aids in facilitating sleep initiation and enhancing sleep maintenance. In contrast to traditional treatments that primarily target GABA and melatonin receptors to promote sleep drive, Lemborexant and other orexin antagonists work to counteract excessive wakefulness. This unique mechanism of action presents potential benefits such as a more favorable side effect profile and potentially greater effectiveness compared to conventional hypnotic medications.
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