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Pemetrexed is a drug that belongs to a class of molecules termed folate antimetabolites and is used in the treatment of aggressive and late stage cancers. Pemetrexed inhibits three enzymes involved in the folate pathway: thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).
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