First in the Industry to use Revolutionary Dry Ice Shipping Solution for APIs that Require Below -70°C

At TAPI, a stand-alone business unit within Teva Pharmaceutical Industries Ltd., we are committed to continually improving our operations, enhancing our services, and reducing our environmental impact. In the last few months, we’ve done exactly that with regards to how we safely and reliably transport API s below -70°C.

We are proud to be the first API manufacturer to partner with Envirotainer AB, introducing their revolutionary -70°C dry ice shipping solution, CryoSure®, to our customers. This innovative technology is currently the only one of its kind on the market , enabling both local and global access to safe distribution of pharmaceuticals and patient samples.

We have started using CryoSure® to ship Caspofungin API across Europe, and the results have been outstanding both operationally and environmentally compared to the solution used so far.

The Operational Front

Flight Flexibility:
Using significantly less dry ice then what TAPI has been using so far (7kg vs. 160kg* per box ) has minimized airline approval requests and delays, streamlining the shipping process and making it easier to get products on flights.

Easy Handling:
Our customers report that the API is much simpler to extract from the CryoSure® unit, thanks to a metallic barrier that separates the dry ice from the product space . This innovation reduces the time needed to access the product compared to traditional method.

Reduced Temperature Deviations:
CryoSure®’s exceptional insulation has significantly improved the previous performance duration by maintaining deep freeze temperatures, making it more resilient to supply chain disruptions. The hard foam inner box and aluminum exterior provide additional protection against vibration and movement during transport.

Real-time Visibility:
With CryoSure®, we now have live monitoring capabilities, offering real-time information on temperature and location . This gives us full visibility and the ability to take immediate action if needed.

* Envirotainer AB

The Environmental Front

Up to 6X Lower Carbon Footprint **:

The reduced dry ice usage and smaller shipment volume mean each pallet can now carry four Cryosure boxes rather than just one of the previous solution’s boxes . This efficiency compared to the previous solution leads to up to six times fewer CO2 emissions, assuming the CryoSure ® X11 units will be reused .

Reusable Units:

The units are completely reusable ***, significantly reducing landfill waste. Once the API is extracted, customers simply attach a pre-printed label to the box and coordinate a pickup time.

Looking Ahead
As we continue to implement this solution and explore its application to other products, we remain dedicated to finding and utilizing innovative and effective solutions that benefit the needs of our customers, our operations and the environment.

* TAPI’s previous packaging solution used 160kg of dry ice per box.

** Based on a life cycle assessment (LCA) for the CryoSure X11 conducted and quality checked by the third-party climate consultancy firm 2050 AB for Envirotainer, utilizing data from Envirotainer and Teva API.
The CryoSure X11 unit holding up to around 7 liters in its inner compartment generates an average of 120.9 kg CO₂ per typical shipment route**** , compared to 724.7 kg CO₂ generated by conventional dry-ice box packaging, when based on the following assumptions:
• The life cycle assessment covers the following stages: Raw material extraction and pre-production; production and assembly; Use (logistics); and End-of-Life.
• Results are based on a typical travel route. The CryoSure packaging option includes the additional travel steps required to reach the Teva API site and its repositioning to the origin Envirotainer station after use.
• Assumes each CryoSure X11 unit is reused 180 times versus 1 time for the conventional packaging option.

***According to Envirotainer’s estimates, each CryoSure X11 unit can be reused approximately 180 times.
**** The typical shipment route from India to Europe (AMS – BOM by air, BOM – Gajraula India, Gajraula – DEL by truck, DEL – AMS by air, AMS – Athens and Athens – AMS both by truck; flight emissions RFI factor 1.0.